process equipment design and fabrication

BioPharm Engineered Systems is an industry leading provider of high quality biopharm process equipment skids with an installed base exceeding 1000 systems. We design (mechanical, electrical, process, controls and software), and fabricate in our own shop, to offer a true turnkey solution. Known best for our TFF and Chromatography skid systems, we also design and fabricate bioreactor/fermentation systems, centrifuge skids, CIP systems, buffer dilution systems, filter housings/skids, and other custom biopharmaceutical processing systems.

Life Science tangential flow filtration equipment

TFF/UF/MF equipment

Tangential Flow Filtration Systems
BPES Tangential Flow Filtration Systems are designed and built to the specific requirements of microfiltration, ultrafiltration, or reverse osmosis applications.  Our process development team works closely with the client to generate a system specification that meets their processing requirements.  Typical TFF applications include fermentation cell culture clarification, diafiltration, protein purification/concentration, and blood fractionation processing.

Each system is designed to maximize product recovery, maximize yield, and minimize its overall footprint.  Ease of use for the operator is always paramount during the design layout process.  BPES custom TFF Systems can vary in their size and complexity.  Systems are designed to incorporate any commercially available membrane configurations and molecular weights.  Our expertise ranges from manual benchtop systems to large (>200m2), fully factory integrated production systems.  No job is too small, and no job is too large!

Biopharmaceutical Chromatographic Separation Equipment

Chromatography feed

Chromatography Systems BPES Chromatography Systems are designed and built to provide outstanding separation and purification performance. Our process engineering team helps define the chromatography process steps needed to optimize production.  Chromatography Systems are available with simple isocratic gradients to complex linear gradients. Mixing can be generated via valve or pump based algorithms.  Gradient accuracies of less than 0.5% are readily achievable.  Typical flow rates range from 0.3 lpm to 50 lpm.  Our flexibility in the choice of a column supplier is an advantage to the customer.  We can use your specified column or the BPES team can source the column.  In either case, we will provide a fully integrated system and perform complete testing on our shop floor.

Custom Designed Process Equipment, filter housings and housing skids

Class 1 Div 2 Skids

Filter Housings and Housing Skids
BPES designs and fabricates custom sanitary filter housings for the biopharmaceutical industry.  Our filter housings are customized in a variety of ways to meet your flow needs. Typical modifications include In-Line/T-Line, number of cartridges, cartridge length, inlet/outlet connections and vent/drain configurations. ASME Stamped and cartridge code Housings are available for sanitary and industrial applications.  Our Design Team will generate a detailed housing drawing and spare parts list.  Our Quality Team ensures that our housings meet all surface finish, code, dimensional, and configuration specifications.

In addition, we design and fabricate filter housing skids for mobile applications.  The same principles which apply to system design are incorporated within our filter housing skid layouts.  Care is taken to minimize the overall skid footprint and facilitate cleanability.  Call with your specific product needs.

Custom Modularized process equipment and centrifuge systems

Centrifuge skid

Centrifuge Systems
 designs and manufactures complete Centrifuge System assemblies.  System design capabilities range from portable manual systems for lab or pilot use to fully automated/integrated large scale production skid systems.  Our biopharm fluid handling expertise provides added value to the centrifuge separation process.